PhD position | ‘Neuroimaging biomarkers in preclinical Alzheimer’s disease’


Your challenge
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that eventually results in dementia. As pathological changes start to arise 15 to 20 years before the onset of dementia, secondary prevention strategies could improve the prognosis of the disease if relevant biomarkers would be available for identification. The European Prevention of Alzheimer’s Dementia (EPAD) project is currently carrying out a longitudinal multinational cohort study with the aim of identifying a population with increased risk of AD dementia that can be potentially treated in clinical trials with the objective to streamline the testing and development of preventative treatments for Alzheimer’s disease (http://ep-ad.org). Neuroimaging allows the detection of early structural and functional changes and might provide useful diagnostic and prognostic biomarkers in preclinical AD. The objective of this project is to identify through neuroimaging an at-risk cohort for secondary prevention of AD dementia.

The most important duties and responsibilities as a PhD student are:

  • Visual assessment of MR scans from all EU sites;
  • Conducting multi-modal imaging analyses, including fMRI, DIT and ASL;
  • Statistical modelling of imaging data and other biomarkers;
  • Writing scientific papers resulting in a PhD thesis.
Your profile
We are seeking a PhD candidate who meets the following requirements:

  • A master degree in medicine, neuroscience, bioinformatics, computer science, artificial intelligence or a similar field;
  • Affinity with programming and biostatistics;
  • Experience with neuroimaging data;
  • Interest in dementia and/or cognitive decline.
Your work environment
The project is part of EPAD project and it will be carried out within the Department of Radiology and Nuclear Medicine in close collaboration with the Alzheimer Centre of Amsterdam UMC – Location VUmc. These centres have a worldwide reputation for cutting-edge research and care in dementia. The work environment is stimulating, collaborative and dynamic with a strong focus on quantitative image analysis and disease modelling.

We offer
Salary Scale PHD: 2357 tot 3020 euro gross when employed full-time (depending on qualifications and experience).

In addition, we offer:
– Additional benefits include an 8.3% end-of-year bonus and 8% holiday pay.
– Your pension premium will be paid by us for 2/3.
– We reimburse 75% of your OV travel costs (commuting costs).

It is a 3-year promotion project. We initially offer a contract for 1 year, which can be extended by mutual agreement.

For more information about our employment conditions, please visit our website.
For Dutch citizens it is mandatory to provide a VOG (a declaration of good behaviour).

Additional information
The starting date for this position is 1 August 2019. The interviews will take place at the end of June. We kindly ask you to take this into account.

Interested?
Don’t hesitate to call us!
If you’re interested about this position, you can contact prof. dr. Frederik Barkhof, via telephone number 020-444 5635.
If you need more information about the application procedure, contact Brend de Jong, corporate recruiter at 020-444 5635.

You can apply till 16 June 2019 by using the apply button.

Acquisition based on this vacancy is not appreciated.

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